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KMID : 0351619680090020091
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Kyungpook Medical Journal
1968 Volume.9 No. 2 p.91 ~ p.122
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Studies on the Effects of Cyclophosphamide on the Growth of Various Organs of Chick Embryo
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Abstract
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420 fertilized white Leghorn eggs were incubated and injected O.OSmg: or O. lmg of cyclophosphamide into chorioa´llantoic membrane on the 6th or 8th day of incubation.
Whole body, brain, eye-ball, heart, lung, liver and kidney were weighed on the 12th, 13th, 14th, 15th, 16th, 17th, and 18th day of incubation and compared- with that of control: group.
The effects of cyclophosphamide on the mitotic coefficient in liver were also studied microscopic-ally.
The effects of injection time and dosage of cyclophosphamide on developing chick embryo were analyzed by the growth formula and the results were obtained as followings.
1. The growth of chick embryos was markedly inhibited bg cyclophosphamide treatment.
The growth inhibitory effect was more significant in the 6th day treatment group compared" with that of 8th day treatment group, with they exception of heart and kidney which showed no noticeable difference in both groups.
Increasing the dosage of cyclophosphamide from. 0.05mg to O.lmg, more significant growth inhibition was observed in body weight, eye-ball and heart but t;he difference was not found in brain, lung, liver and kidney.
2. Specific growth rate was significantly low in body weight, eye-ball and liver of the 6th day treatment F;roup and body weight, brain, lung, and heart of the 8th day treatment group.
3. Mitotic coefficient in liver was lower in the 6th day treatment group than that of the 8th day treatment group, but no significant difference was observed between O.OSmg and 0.1 mg injected groups.
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